Stress has a well-documented influence on gastrointestinal function, often triggering loose watery bowel movements through the gut–brain axis. Psychological stress can accelerate intestinal motility, alter gut microbiota, and increase intestinal permeability, all of which contribute to diarrhea-like symptoms. Hormonal responses, particularly cortisol release, further disrupt normal digestive regulation. Individuals under chronic stress may therefore experience recurrent bowel irregularities without underlying infection. From a healthcare supply perspective, distributors such as a nizonide wholesaler often observe increased interest in gastrointestinal medications during high-stress periods, highlighting the close relationship between emotional wellbeing and digestive health in modern populations.